The 51 Leslie bus route operates between Eglinton Station on the Yonge-University-Spadina Subway and the area of Steeles Avenue East and Don Mills Road, generally in a north-south direction. It also serves the Leslie Station on the Sheppard Subway. Accessible service is provided on the route. Both Eglinton and Leslie Stations are accessible subway stations. Bike racks are available on this route.

One single service is operated: the 51 (Eglinton Stn-Steeles) branch operates at all times, seven days a week.

Northbound 51 TO STEELES

These buses operate from Eglinton Station via north on Duplex Avenue, east on Eglinton Avenue East, north on Leslie Street, east and north through the North York General Hospital grounds, west and north on Old Leslie Street, through Leslie Station, continuing south and east on Old Leslie Street, north on Leslie Street, east on Steeles Avenue East, and south on Townsend Road to Freshmeadow Drive.

Southbound 51 TO EGLINTON STN

These buses operate from Townsend Road and Freshmeadow Drive via west on Freshmeadow Drive, north on Don Mills Road, west on Steeles Avenue East, south on Leslie Street, west on Sheppard Avenue East, west and south on Old Leslie Street, through Leslie Station, continuing south and east on Old Leslie Street, south and west through the North York General Hospital grounds, south on Leslie Street, west on Eglinton Avenue East, south on Yonge Street, and west on Berwick Avenue to Eglinton Station.

All buses on the route serve local bus stops along the route.