The 22 Coxwell bus route operates between Coxwell Station on the Bloor-Danforth Subway, the area of Coxwell Avenue and Queen Street East, and Bingham Loop, generally in a north-south direction. Bike racks are available on this route. Accessible service is provided on the route.

Two services are operated.  The 22 (Coxwell Stn-Queen) is the main branch, and operates during the peak periods and midday, from Monday to Friday only.  The 22A (Coxwell Stn-Victoria Park) extended branch operates during the evening from Monday to Friday, and at all times on Saturdays, Sundays and holidays.

Southbound 22 TO QUEEN

These buses operate from Coxwell Station via west on Strathmore Boulevard, south on Coxwell Avenue, east on Queen Street East, and south and west on Eastern Avenue to Coxwell Avenue.

Northbound 22 TO COXWELL STN

These buses operate from Eastern Avenue and Coxwell Avenue via north on Coxwell Avenue, and east on Strathmore Boulevard to Coxwell Station.

Southbound 22A TO VICTORIA PARK VIA KINGSTON RD

These buses operate from Coxwell Station via west on Strathmore Boulevard, south on Coxwell Avenue, east on Queen Street East, north and east on Kingston Road, north on Victoria Park Avenue, and west through Bingham Loop.

Northbound 22A TO COXWELL STN

These buses operate from Bingham Loop via south on Bingham Avenue, west and south on Kingston Road, south and west on Eastern Avenue, north on Coxwell Avenue, and east on Strathmore Boulevard to Coxwell Station.

All buses on the route serve local bus stops along the route.